Fig 2. Diabetes-associated genes form a protomodule.
(A) Overall, 452 diabetes-associated gene (DAGs; GWAS p value < 5 x 10−8 and OMIM) products form a PPIN of 184 proteins and 309 interactions termed T2D-protomodule. (B) In total, 10% (11/102) of the high-confidence DAGs with a probability less than 5 x 10−8, 53% of the DAGs with a probability less than 1 x 10−8 (141/266) and 49% of the OMIM genes (49/84) are recovered in the proto-T2D module, showing a tendency to select the highest level of reliability. (C) Nodes–degree distribution: More than 38% of nodes (70 nodes) in the proto-T2D module are peripheral with a minority of hubs from transcription factor families. The general topology of the protomodule is characteristic of a disease network with the presence of few central hubs of large size, surrounded by numerous peripheral hubs of smaller size (S3 Table).