Fig. 10.
Effects of POEG-b-PPPMP and POEG-b-PPPMP/DOX on GCS mRNA expression in MCF-7 (A) or 4T1.2 (B) cells after 48 h treatment compared to free drug alone or combination. Tumor cells were treated with PPMP, POEG-b-PPPMP, DOX·HCl+PPMP or POEG-b-PPPMP/DOX at the same PPMP concentration of 1.7 μM; DOX·HCl, DOX·HCl+PPMP or POEG-b-PPPMP/DOX at the same DOX concentration of 100 nM. Data are presented as the means ± SD for triplicate samples. P values were generated by one-way ANOVA using the Tukey test for multiple comparisons. *P < 0.05, **P < 0.01, *** P < 0.001.