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. Author manuscript; available in PMC: 2019 Oct 28.
Published in final edited form as: J Control Release. 2018 Sep 14;288:212–226. doi: 10.1016/j.jconrel.2018.09.011

Fig. 11.

Fig. 11.

(A) Pharmacokinetics of DOX·HCl, POEG-b-POM/DOX and POEG-b-PPPMP/DOX micelles in tumor-free female CD1 mice. (B) Tissue distribution of DOX 24 h post injection in tumor-bearing female BALB/c mice treated with DOX·HCl, POEG-b-POM/DOX or POEG-b-PPPMP/DOX micelles at the same dose of 5mg DOX/kg. Values reported are the means ± SEM, n=5. P values were generated by two-way ANOVA using the Tukey test for multiple comparisons. *P < 0.05, *** P < 0.001 (POEG-b-PPPMP/DOX vs DOX·HCl; &P < 0.05 (POEG-b-POM/DOX vs DOX·HCl); ###P < 0.001 (POEG-b-PPPMP/DOX vs POEG-b-POM/DOX).