Cumulative DOX release profile from POEG-b-PPPMP micelles with free DOX and POEG-b-POM micelles as control. (A) 0 to 72 hours, (B) 0 to 12 hours. DPBS was used as the release medium. DOX concentration was fixed at 0.5 mg/mL. Values reported are the means ± SD for triplicate samples. Statistical significance was determined by two-way ANOVA using the Tukey test for multiple comparisons. *P < 0.05, **P < 0.01, *** P < 0.001 (POEG-b-PPPMP/DOX vs free DOX); #P < 0.05, ##P < 0.01, ###P < 0.001 (POEG-b-PPPMP/DOX vs POEG-b-POM/DOX).