Figure 2. Commd1 Deficiency Impairs Bacterial Clearance in the Colonic Lamina Propria.

(A) Representative images (from over 5 independent iterations) of a polypstained by FISH with a eubacterial probe (green) and concurrently stained for F4/80 (red) and nuclei (blue). Scale bar, 100 μm.

(B) Representative images of FISH staining of polyps (from over 5 independentiterations) demonstrating bacterial penetration into the colonic lamina propria in Commd1^fl/fl or Commd1^ΔMye mice carrying the Apc^Min allele. Scale bars, 100 μm.

(C) Quantification of the imaging shown in (B), expressed as fold over the Commd1^fl/fl group (three animals per group). Data displayed indicate mean and SEM; **p < 0.01 (unpaired Student’s t test).

See also Figure S2A.