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. Author manuscript; available in PMC: 2020 May 1.
Published in final edited form as: Biochim Biophys Acta Mol Basis Dis. 2018 Apr 5;1865(5):982–992. doi: 10.1016/j.bbadis.2018.03.026

Table 2.

Evaluation of Animal Models of CCA.

• Anatomic Localization within the Liver
  • ○

    Liver parenchyma and/or large bile ducts

  • ○

    Metastasis

• Liver Injury/Dysfunction
  • ○

    AST, ALT, Serum bilirubin levels

• Histopathologic Characterization
  • ○

    H&E

  • ○

    IHC for SOX9, CK-7, and CK-19

• Genetic Characterization
  • ○

    RNA-Seq

  • ○

    Mate pair sequencing for chromosomal instability

• Animal Consequences
  • ○

    Metastasis

  • ○

    Survival

ALT, alanine aminotransferase; AST, aspartate aminotransferase; H&E, hematoxylin and eosin; IHC, immunohistochemistry; RNA-Seq, RNA sequencing