Table 2.
Regulation of macrophage non-coding RNAs in atherosclerosis
| ncRNA | mRNA target | Function | Regulation | Atherosclerosis outcome | References |
|---|---|---|---|---|---|
| miR-21 | STAT3, SOCS1, MKK3 | ↓Lipid uptake and inflammation | Induced in plaques | Anti | [194, 195] |
| miR-33 | AMPK, | ↑Inflammation | Pro | [167, 168] | |
| miR-125 | KLF13 | ↓TH1 response | Induced by TLRs | Anti | [193] |
| miR-146 | IRAK1, TRAF6 | ↓Inflammation | Up in athero plaques | Anti | [150, 184] |
| miR-150 | c-Myb | ↑EC migration | Secreted, ↑with inflammatory stimuli | Pro | [206] |
| miR-155 | SOCS-1, BCL6, IL-13Ra1, CARHSP1 | ↑Inflammation through SOCS-1, BCL6 ↓Inflammation through CARHSP1 | Induced by oxLDL, TLRs | Pro and anti | [176–179] |
| miR-223 | PKNOX, CXCL2, CCL3 | Suppress M1 activation | Anti | [191, 192] | |
| miR-342–5p | AKT-1 | ↑Inflammation | ↑in athero plaques | Pro | [182] |
| LncRNACox2 | hnRNPAB, SWI/SNF | Inflammatory activation | Induced by proinflammatory cytokines | Unknown | [196–198] |
| THRIL | hnRNPL | ↑TNFα induction | Induced by Pam3CSK4 | Unknown | [199] |
| RP-833A20.1 | miR-382–5p | Suppresses cholesterol and inflammation | ↑ in human foam cells | Unknown | [31] |
| E330013 | Unknown | Promotes M1 activation | Up in macrophages of diabetic mice | Unknown | [201] |