Table 2.

Association between baseline biochemical markers and baseline severity of MRI features.

	Biochemical marker*	P valuefor trend	0	1	2–3
Hoffa-synovitis	sColl2,1NO2 (nM)	0.493
	Mean (SD)	-	9.31 (5.97)	9.01 (7.40)	8.32 (4.03)
	OR (95% CI)	-	REF	0.97 (0.82, 1.15)	0.91 (0.62, 1.35)
	sHA (ng/mL)	0.132
	Mean (SD)	-	43.93 (45.33)	50.61 (43.46)	46.79 (34.15)
	OR (95% CI)	-	REF	1.14 (0.93, 1.39)	1.15 (0.83, 1.58)
	sMMP-3 (ng/mL)	0.074
	Mean (SD)	-	16.90 (16.75)	17.98 (14.79)	20.34 (9.56)
	OR (95% CI)	-	REF	1.07 (0.88, 1.30)	1.04 (0.76, 1.42)
Effusion-synovitis	sColl2,1NO2 (nM)	0.641
	Mean (SD)	-	8.78 (5.20)	9.38 (8.40)	8.46 (3.87)
	OR (95% CI)	-	REF	1.07 (0.87, 1.32)	1.06 (0.83, 1.34)
	sHA (ng/mL)	0.007
	Mean (SD)	-	44.29 (43.88)	45.72 (39.08)	57.86 (45.38)
	OR (95% CI)	-	REF	0.99 (0.79, 1.24)	1.35 (1.07, 1.71)
	sMMP-3 (ng/mL)	0.032
	Mean (SD)	-	16.98 (17.18)	16.90 (12.71)	21.68 (16.64)
	OR (95% CI)	-	REF	1.12 (0.87, 1.45)	1.30 (1.00, 1.69)

Adjusted for age, gender, BMI, baseline KLG.

^*Mean and standard deviation (SD) of biochemical markers are presented as non-transformed values. Odds ratio were calculated using baseline values of biochemical markers transformed to z values.