Table 1.

Effect of oxygen tension on cancer therapy^a

Critical O2 tension (mmHg)	Function or parameter observed
30–35	Effectiveness of certain (passive) immunotherapies
15–35	Cell death with PDT
25–30	Cell death on exposure to χ- and γ-radiation
10–20	Binding of hypoxia markers
1–15	Proteome changes
0.2–1	Genome changes

Note:

^aReformatted from Höckel M, Vaupel P, Tumor hypoxia: definitions and current clinical, biologic, and Molecular Aspects. J Natl Cancer Inst. 2001;93(4):266–276, by permission of Oxford University Press.¹⁵

Abbreviation: PDT, photodynamic therapy.