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Pharmacokinetic parameters of DOX after intravenous injection (n=4)
| Parameters | Free DOX | HMCN(DOX)@GQDs | HA-HMCN(DOX)@GQDs |
|---|---|---|---|
|
| |||
| t1/2β (hours) | 0.83±0.19 | 6.76±0.57 | 6.12±0.45 |
| Cmax (µg/mL) | 12.84±1.1 | 16.76±0.72 | 15.02±1.3 |
| AUC0–∞ (µg/mL·h) | 8.67±1.23 | 104.16±14.35 | 99.96±12.17 |
| MRT (hours) | 0.93±0.26 | 9.46±1.32 | 9.15±1.21 |
Abbreviations: AUC, area under the curve; DOX, doxorubicin; GQDs, graphene quantum dots; HA, hyaluronic acid; HMCN, hollow mesoporous carbon nanoparticle; MRT, mean residence time.
