. 2018 Oct 4;11:6415–6424. doi: 10.2147/OTT.S167853

Table 2.

Summary of lncRNAs used as prognostic biomarkers of bladder cancer

Study	Region	LncRNA	Expression	Detected sample	Test method	Cut-off	Sample size		Survival analysis	HR availability	Follow-up month	NOS
Study	Region	LncRNA	Expression	Detected sample	Test method	Cut-off	High	Low	Survival analysis	HR availability	Follow-up month	NOS
Ariel et al, 2000³¹	Israel	H19	Up-regulation	Tissue	RT-qPCR	NA	16	14	OS	Indirectly	80	5
Wang et al, 2013¹³	China	UBC1	Up-regulation	Tissue	RT-qPCR	FC >1.5	60	42	OS MFS	Indirectly Indirectly	80	5
Li et al, 2014³²	China	GHET1	Up-regulation	Tissue	RT-qPCR	Median	39	41	OS	Indirectly	60	6
Zhao et al, 2015¹⁵	China	SPRY4-IT1	Downregulation	Tissue	RT-qPCR	Mean	38	30	OS	Directly	NA	5
Martínez- Fernández et al, 2015³³	Spain	HOTAIR	Up-regulation	Tissue	RT-qPCR	Median	30	33	PFS OS	Indirectly Indirectly	36 72	5
Chen et al, 2015³⁴	China	n336928	Up-regulation	Tissue	RT-qPCR	FC >2	44	51	OS	Directly	60	5
Heubach et al, 2015³⁵	Germany	HOTAIR	Up-regulation	Tissue	RT-qPCR	FC >2	27	81	DSS	Directly	200	6
Duan et al, 2016²⁸	China	MEG3	Downregulation	Serum	RT-qPCR	NA	26	33	RFS	Indirectly	57	7
Zhang et al, 2016³⁶	China	UNMIBC	Up-regulation	Tissue	RT-qPCR	FC >1.5	42	33	RFS	Directly	36	6
Zhang et al, 2016³⁷	China	GAS5	Downregulation	Tissue	RT-qPCR	Median	41	41	DFS	Directly	60	7
Shang et al, 2016³⁸	China	HOTAIR	Up-regulation	Tissue	RT-qPCR	NA	16	19	OS	Indirectly	40	5
Iliev et al, 2016³⁹	Czech Republic	TUG1	Up-regulation	Tissue	RT-qPCR	NA	26	21	OS	Directly	100
Yan et al, 2017²³	China	ASAP1-IT1	Up-regulation	Tissue	RT-qPCR	Median	19	19	OS	Directly	44	6
Droop et al, 2017⁴⁰	Germany	MALAT1 TUG1 UCA1 UBC1 NcRAN GAS5 H19	Downregulation Downregulation Downregulation Downregulation Downregulation Downregulation Downregulation	Tissue	RT-qPCR	Median	53	53	OS DSS	Directly Directly	200 200	6
Wang et al, 2017⁴¹	China	HULC	Up-regulation	Tissue	RT-qPCR	Median	138	138	RFS	Indirectly	14	5
Zhuang et al, 2017⁴²	China	LET	Downregulation	Tissue	RT-qPCR	Median	30	30	OS	Indirectly	48	6

Abbreviations: DFS, disease-free survival; DSS, disease-specific survival; FC, fold change; lncRNA, long non-coding RNA; MFS, metastasis-free survival; NOS, Newcastle-Ottawa Scale; OS, overall survival; PFS, progression-free survival; RFS, recurrence-free survival.