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. 2018 Oct 9;8:15009. doi: 10.1038/s41598-018-33391-1

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Schematic representation of C. rosea putative PKS biosynthetic gene clusters (BGCs) showing similarity with genes from characterised BGCs. (A) Citrinin BGC, (B) Sorbicillin BGC, and (C) Depudicin BGC. Type of genes common (≥40% sequence identity; e- value ≥1 × 10²⁵) between two BGC are highlighted with the same colour, white arrows represent genes that are not common between BGC. Genes name are given in parentheses below the arrow, their orientation are indicated, while distance and size are not set to scale. C. rosea protein IDs are given above the arrows. Genbank accession numbers: citA: ALI92654.1; citS: ALI92655.1; orf1: CAP95402.1; sorB: CAP95404.1; sorC: CAP95405.1; orf5: CAP95406.1; orf6: CAP95407.1; dep2: ACZ57545.1; dep3: ACZ57546.1; dep4: ACZ57547.1; dep5: ACZ57548.1.