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. 2018 Oct 9;8:15029. doi: 10.1038/s41598-018-33239-8

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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CHI3L1 promotes cancer cell proliferation in vivo and in vitro. (a,b) CHI3L1 overexpression and knockdown cells and the control cells were seeded into 96 well plate. Cells were treated with MTT and the MTT absorbance value was measured at 8 h, 24 h, 48 h, 72 h and 96 h after cell seeding. (c,d,g,h) Representative images, growth and weight of tumors following subcutaneous injection of the HepG2-shCHI3L1, Bel7404-CHI3L1 or the control cells. (e,i,f,j) CD31 stain of the tumors formed by injection of the HepG2-shCHI3L1 and Bel7404-CHI3L1or the control cells. Scale bar represent 200 μm. * and ** represent p < 0.05 and p < 0.01 by two-tailed t test.