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. 2018 Oct 9;8:15029. doi: 10.1038/s41598-018-33239-8

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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CHI3L1 can activate TGF-β signaling pathway. (a–c) Western blot showing CHI3L1 activated the TGF-β signaling pathway in Bel7404 and HepG2 cells. (d) The SDS-PAGE picture of rCHI3L1. The arrow points to the protein band representing rCHI3L1. (e–g) TGF-β signaling pathway could be activated by rCHI3L1 in Bel7404 and HepG2 cells.