Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Oct 9;8:15010. doi: 10.1038/s41598-018-33462-3

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Effects of cetuximab treatment on skin microtissue at day 5 of co-culture. (a) H&E staining of untreated control group indicating maintained columnar basal keratinocyte layer. (b) Immunofluorescent TUNEL (green) and Ki67 (red, arrows) staining of untreated control group indicating proliferative keratinocytes in the basal layer. (c) H&E staining of antibody-exposed group showing irregular arrangement of keratinocytes in the stratum basale. (d) Immunofluorescent TUNEL (green) and Ki67 (red) staining of antibody-exposed group demonstrating complete lack of proliferative cells. (a,c) Dotted lines (orange) framing keratinocytes inside the stratum basale. (b,d) Nuclei stained with DAPI (blue). Scale bar: 100 µm. (e) Gene expression of tumour necrosis factor alpha (TNFα) and Keratin 1 (KRT1) in skin microtissue of untreated control group (white bars) and antibody exposure group (black bars), n = 3. Data shown as mean + SD.