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. 2018 Oct 9;28:37. doi: 10.1038/s41533-018-0106-6

Table 2.

Number and percentages of chronological order of events per group of patients with the same diagnosis and the number and percentage of combination inhalers (i.e. ICS plus long-acting bronchodilator) as first prescription in patients with ICS maintenance treatment

Chronological order of events Total Combination inhaler
First eventa Second eventa Third eventa n (%) n (% of total)
Asthma (n = 8,507) Asthma → ICS 7525 (88.5) 3294 (43.8)
ICS → Asthma 982 (11.5) 514 (52.3)
COPD (n = 4,024) COPD → ICS 3188 (79.2) 2232 (70.0)
ICS → COPD 836 (20.8) 598 (71.5)
ACO (n = 801) Asthma → ICS → COPD 131 (16.4) 69 (52.7)
Asthma → COPD → ICS 124 (15.5) 67 (54.0)
COPD → ICS → Asthma 31 (3.9) 17 (54.8)
COPD → Asthma → ICS 59 (7.4) 35 (59.3)
ICS → Asthma → COPD 27 (3.4) 12 (44.4)
ICS → COPD → Asthma 12 (1.5) 7 (58.3)
Asthma/COPD → ICS 376 (46.9) 240 (63.8)
ICS → Asthma/COPD 41 (5.1) 29 (70.7)
Total (n = 13,332) 7114 (53.4)

ACO asthma–COPD overlap, COPD chronic obstructive pulmonary disease, ICS inhaled corticosteroids

aEvent: diagnosis of asthma ('asthma'), or diagnosis of COPD ('COPD'), or diagnosis of asthma and COPD ('asthma/COPD') on the same calendar date, or start of ICS treatment ('ICS')