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. 2018 Oct 9;8:14989. doi: 10.1038/s41598-018-33098-3

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Global View of Identified LAMA2 Intragenic CNVs. The genomic structure of LAMA2 is presented in UCSC Genome Browser GRCh37/hg19, and custom tracks show LAMA2 intragenic CNVs. In-frame deletions were annotated with light blue color, out-of-frame deletions were annotated with dark blue color, and duplications were highlighted in red color. CNV in P21 was large and exceeded the coverage of the LAMA2-target aCGH utilized in this study, the dotted line was used to indicate the location of the uncertain breakpoint downstream.