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. 2018 Oct 9;8:14991. doi: 10.1038/s41598-018-33112-8

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Displays the correlations of mean myelin water fraction (MWF) values and age. Declines of the MWF in the frontal and parietal WM were highly correlated with age. Moderate negative correlations of the MWF with age were found for the genu and splenium of corpus callosum. Upper and lower curved graphs are indicating the 95% confidence interval of the mean value. No significant correlation with age was found for the ROI in the occipital WM and the corticospinal tract. r = correlation coefficient; significant results (p < 0.001) are marked with an asterisk.