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. 2018 Oct 9;8:15039. doi: 10.1038/s41598-018-33280-7

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Protein enrichment analysis. Mean values of protein expression was used to calculate fold change (FC) of particular proteins between ELV-UP (a), ELV-MV (b) and MV-UP (c), in which FC >1, <1, and = 1 indicated enrichment, depletion and no change, respectively. Selected biomarkers were labeled to facilitate visual interpretation. Common exosome markers were marked in red color. Tissue-localized markers were labeled in green color. Exosome-associated proteins were labeled in black color. Selected urine biomarkers were labeled in blue color.