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. 2018 Oct 9;8:14997. doi: 10.1038/s41598-018-33387-x

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Morphology of placentas derived from WT in comparison to heterozygous (Hetero) or homozygous (KO) Math6 deficient females at day E10.5. The decidua is located between the labyrinth + junctional zone (L + J) and the myometrium (M) and appeared semicircular in pregnant WT females (A). Complete (B and D) but not partial (C) lack of maternal Math6 led to an altered shape of the placenta with the junctional zone, labyrinth and chorionic trophoblast (Ch) convexly bulging into a crescent-shaped decidua (B/D). Additionally, the number of trophoblast giant cells in the junctional zone (black arrows) was increased in placentas lacking maternal Math6 (compare A′and B′). The placenta phenotype is independent of the paternal i.e. the resulting embryonic Math6 genotype (compare B and D).