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. 2018 Oct 4;10:4191–4202. doi: 10.2147/CMAR.S178219

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© 2018 Lin et al. This work is published and licensed by Dove Medical Press Limited

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PKM2 expression is increased in CC.

Notes: (A) Significant upregulation of PKM2 mRNA expression level was observed in CC tissues compared with paired adjacent nontumor ones; β-actin was used as the loading control. (B) Western blot was conducted to examine the expression levels of PKM2 in seven CC tissue specimens and their matched adjacent nontumor ones; PKM2 expression was significantly higher in the seven tumor tissues than in the matched paracancerous controls. N: adjacent nontumor tissues; T: CC tissue. (C) PKM2 mRNA in cervical cell lines was detected using qRT-PCR and relative quantification analysis was normalized to β-actin mRNA. (D) PKM2 protein expression was analyzed in CC cell lines using Western blot. ***P<0.001.

Abbreviations: CC, cervical cancer; GAPDH, glyceraldehyde-3-phosphate dehydrogenase; PKM2, pyruvate kinase isozyme type M2; qRT-PCR, quantitative real-time polymerase chain reaction.