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. 2018 Oct 4;10:4191–4202. doi: 10.2147/CMAR.S178219

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© 2018 Lin et al. This work is published and licensed by Dove Medical Press Limited

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Effect of PKM2 on EMT and the Wnt signaling pathway.

Notes: (A) The effect of PKM2 knockdown on the expression of E-cadherin, vimentin, Snail, and Slug were assessed by Western blot in HeLa and SiHa cells. β-catenin and downstream target genes c-Myc and cyclin D1 were assessed by Western blot after knockdown of PKM2. (B) The effects of PKM2 upregulation on protein levels of E-cadherin, vimentin, Snail, Slug, β-catenin, c-Myc, and cyclin D1; GAPDH level was used as a loading control.

Abbreviations: EMT, epithelial–mesenchymal transition; GAPDH, glyceraldehyde-3-phosphate dehydrogenase; PKM2, pyruvate kinase isozyme type M2; shPKM2, shRNA against PKM2.