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. Author manuscript; available in PMC: 2019 Jul 20.
Published in final edited form as: ACS Synth Biol. 2018 Jul 10;7(7):1722–1729. doi: 10.1021/acssynbio.8b00195

Table 2. Genomic mutation rate is unaltered by error-prone TP-DNAP2 variants.

Entries 1–4 are per-base substitution rates of genomic replication in presence of TP-DNAP2 variants, measured using the genomic URA3 locus. Mutagenic TP-DNAP2 variants Y424Q and S370Q cause no statistically significant change in genomic mutation rate, relative to no TP-DNAP2 variant in trans (84% CI overlap method).21 Ranges in parentheses correspond to 95% confidence intervals, determined according to the MSS method.17–19

Entry TP-DNAP2 in trans Per-base substitution rate at genomic URA3 locus (x10−10)
1 None 1.6 (0.8–2.4)
2 WT 2.2 (1.2–3.4)
3 Y424Q 1.8 (1.0–2.9)
4 S370Q 1.8 (1.0–2.8)