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Aromatic residues and negatively charged residues involved in the binding of berberine to OfHex1 (PDB code 5Y0V) (A), QacR (PDB code 3BTI) (B), BmrR (PDB code 3D6Y) (C), and RamR (PDB code 3VW2) (D). Berberine is shown in green. Aromatic and negatively charged residues are shown in yellow and white, respectively.
