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. 2018 Aug 22;293(40):15429–15438. doi: 10.1074/jbc.RA118.004351

Table 1.

K_i values of berberine and its analogs against GH20 and GH18 enzymes

Compound	K_i (μm)
	GH20		GH18			GH84, HsOGA	GH63, ScGluI	GH13, PPA
	OfHex1	HsHexB	OfChtI	HsCht	AMCase	GH84, HsOGA	GH63, ScGluI	GH13, PPA
Berberine	12	240	23	19	65	118	130	NI^a
Thalifendine	11	65	15	15	55	72	74	NI^a
Palmatine	53	300	38	15	70	194	600	NI^a
Tetrahydroberberine	NI^b	NI^b	NI^b	NI^b	NI^b	NI^b	NI^b	NI^b

^a NI indicates not inhibited at a concentration of 400 μm.

^b NI indicates not inhibited at a concentration of 100 μm.