Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
A model of Wnt-mediated autocrine and paracrine regulation of activity-dependent BDNF expression. A, autocrine regulation. Activity-regulated Wnt secretion causes the Wnt/β-catenin signaling-dependent activation of BDNF transcription in the activated neurons. B, paracrine regulation. The extracellular Wnt ligands secreted from the activated neurons may activate BDNF expression in nearby cells, including unstimulated neurons and glial cells.
