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. 2018 Sep 22;175(21):4154–4166. doi: 10.1111/bph.14462

Figure 3.

Figure 3

Comparison of the anti‐allodynic effects of mambalgin‐1, amiloride and sumatriptan on ISDN‐induced cephalic and extra‐cephalic acute mechanical allodynia. (A, B, left panels) Kinetics of the analgesic effects on face (A) and paw (B) mechanical withdrawal force (g), of amiloride (10 mg·kg−1) and sumatriptan succinate (Imiject©, 10 mg·kg−1) i.v. injected 105 min after the injection of ISDN measured on the same rats. Mean ± SEM, n = 9. *P < 0.05 with non‐parametric Kruskal–Wallis and Dunn's post hoc tests compared to vehicle; # P < 0.05 with Wilcoxon matched paired test compared to control value before ISDN injection. For clarity, only vehicle (same data as in Figure 2A,B) but not Mamb‐1 is shown. (A, B, right panels) Total effect of vehicle, Mamb‐1 (same data as in Figure 2A,B), amiloride and sumatriptan on face (A) and paw (B) withdrawal force, calculated as the AUC, during the 2 h after injection. Individual data points and mean ± SEM, n = 9: *P < 0.05 with Mann–Whitney non‐parametric test compared to vehicle; # P < 0.05 with Mann–Whitney non‐parametric test compared to Mamb‐1.