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. 2018 Mar 25;175(21):4047–4059. doi: 10.1111/bph.14160

Figure 2.

Figure 2

Endothelin receptors and ligands. Relative potency of ET isoforms for respective receptors is indicated by thickness of arrows. Potency order of endogenous agonists for ETA receptors: ET‐1 = ET‐2 > > ET‐3. Potency order of endogenous agonists for ETB receptors: ET‐1 = ET‐2 = ET‐3. Compounds mentioned in the text as pharmacological modulators for the ETA and ETB receptors are shown: BQ‐123 (selective ETA receptor antagonist), bosentan (unbiased ETA/ETB receptor antagonist), BQ‐788 (selective ETB receptor antagonist) and sarafotoxin s6c (selective ETB receptor agonist).