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. 2018 Mar 25;175(21):4047–4059. doi: 10.1111/bph.14160

Figure 3.

Figure 3

Metabolic pathways of arachidonic acid. COX‐1/2 metabolism of arachidonic acid produces bioactive eicosanoid hormones; PGI2, TXA2, PGE2, PGD2 and PGF2α. These prostanoids then act at nine cognate GPCRs: IP, TP, EP1–4, DP1,2 and FP receptors. Actions of CYP450 enzymes on arachidonic acid produce 20‐HETE and EETs, which may act through GPCRs. The final metabolic pathway of arachidonic acid produces leukotrienes and lipoxins via lipoxygenase activity, which are not discussed in this review.