Table 3.

Adverse events with possible or probable relationship to eculizumab treatment

Severity/possibly related to treatment	Probably related to treatment
Severe
Peritonitis*	Pneumonia†
Moderate
Hemorrhoidal hemorrhage*	- - -
Fatigue‡
Muscle cramps‡
Arterial stenosis‡
Hypertension
Pruritus
Urinary tract infection
Mild
Limb pain‡	- - -
Oral herpes infection
Fatigue
Creatinine increase (2 episodes)

^*Patient 9 with preexisting liver cirrhosis and clinical suspicion of spontaneous peritonitis (no bacterial pathogen demonstrated).

^†Full recovery without delay of eculizumab administration (patient 14).

^‡Patient 11 with preexisting atherosclerosis and atrial fibrillation, pain in left foot, and cramps in left calf starting in the first month of eculizumab therapy, diagnosis of a stenosis of the left superficial femoral artery in the posttreatment phase.