Table 1.
Comparison of clinical and pathologic characteristics among Bethesda categories III, V, and VI in 1,990 patients with conventional papillary thyroid carcinoma
| Variable | Bethesda classification |
Overall P-valuea) |
Post hoc pairwise P-values with Bonferroni correctionb) |
||||
|---|---|---|---|---|---|---|---|
| Category III (1) (n=98) | Category V (2) (n=730) | Category VI (3) (n=1,162) | (1) vs. (2) | (1) vs. (3) | (2) vs. (3) | ||
| Age (yr) | 46.5±12.7 | 44.0±11.7 | 43.9±12.0 | 0.118 | |||
| Sex | 0.371 | >0.999 | >0.999 | >0.999 | |||
| Male | 72 (73.5) | 581 (79.6) | 911 (78.4) | ||||
| Female | 26 (26.5) | 149 (20.4) | 251 (21.6) | ||||
| US assessment | 0.019 | 0.114 | 0.028 | >0.999 | |||
| Suspicious | 91 (92.9) | 709 (97.1) | 1,137 (97.8) | ||||
| Probably benign | 7 (7.1) | 21 (2.9) | 25 (2.2) | ||||
| Tumor size (mm) | 7.6±5.1 | 8.6±6.1 | 10.4±8.0 | <0.001c) | |||
| Gross extrathyroidal extension | <0.001 | >0.999 | 0.057 | <0.001 | |||
| Yes | 2 (2.0) | 28 (3.8) | 97 (8.3) | ||||
| No | 96 (98.0) | 702 (96.2) | 1,065 (91.7) | ||||
| Central lymph node metastasis | <0.001 | 0.131 | <0.001 | <0.001 | |||
| Yes | 23 (23.5) | 250 (34.2) | 511 (44.0) | ||||
| No | 75 (76.5) | 480 (65.8) | 651 (56.0) | ||||
| Lateral lymph node metastasis | 0.003 | >0.999 | 0.664 | 0.004 | |||
| Yes | 7 (7.1) | 52 (7.1) | 137 (11.8) | ||||
| No | 91 (92.9) | 678 (92.9) | 1,025 (88.2) | ||||
| Multiplicity | 0.103 | >0.999 | >0.999 | 0.138 | |||
| Yes | 29 (29.6) | 217 (29.7) | 398 (34.3) | ||||
| No | 69 (70.4) | 513 (70.3) | 764 (65.7) | ||||
Values are presented as mean±standard deviation or number (%).
US, ultrasonography; ANOVA, analysis of variance.
Calculated using the chi-square test or the Fisher exact test for categorical variables and ANOVA for continuous variables.
Calculated using the chi-square test or the Fisher exact test for categorical variables and the t test for continuous variables. The post hoc pairwise P-values with the Bonferroni correction were calculated by multiplying the pairwise raw P-values by 3, which is the number of comparisons made.
Significant differences were seen between categories III and VI and between categories V and VI, using ANOVA with Bonferroni post hoc analysis.