Table 3.
Comparative bioavailability statistics for doxycycline
| Plasma | |||||
|---|---|---|---|---|---|
| Parameters | Day 1 | Day 14 | |||
| Cmax | AUC0–24 | Cmax | Cmin | AUC0–24 | |
| Geo LSM fed/fasting (90% CI) | 0.89 (0.65, 1.23) | 0.86 (0.69, 1.06) | 0.97 (0.68, 1.37) | 1.10 (0.80, 1.53) | 0.98 (0.73, 1.33) |
| Skin | |||||
| Geo LSM fed/fasting (90% CI) | 0.73 (0.49, 1.08) | 0.68 (0.46, 1.01) | 1.01 (0.70, 1.46) | 0.97 (0.62, 1.50) | 0.94 (0.65, 1.38) |
AUC0–24, area under the curve from zero to 24 h; CI, confidence interval; Cmax, peak concentration; Cmin, trough concentration; Geo LSM, geometric least square means