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. 2018 Sep 6;84(11):2634–2644. doi: 10.1111/bcp.13728

Figure 1.

Figure 1

Effect of (A) loop diuretics and mineralocorticoid receptor antagonists (MRAs) and (B) loop diuretics and eGFRcreat < 60 ml min–1 1.73‐m–2 on trimethylamine‐N‐oxide (TMAO) levels in patients. eGFRcreat, estimated glomerular filtration rate based on the 2009 CKD‐EPI creatinine equation. Values are represented as the mean ± standard deviation [number of patients in each subgroup: (A) n = 266, n = 15, n = 6 and n = 13, and (B) n = 249, n = 32, n = 13 and n = 6, respectively]. *P < 0.05 for posthoc subgroup analyses with Tukey's test compared to the reference group (P values: 0.493, 0.716, 0.042 and 0.013, 0.190, 0.073 for (A) and (B), respectively)