Figure 3.

The effects of acute administration of furosemide and probenecid after concomitant trimethylamine‐N‐oxide (TMAO) administration on the plasma concentration of TMAO in mice. TMAO concentrations were determined in plasma samples up to 4 h after TMAO (10 mg kg^–1) administration with furosemide (50 mg kg^–1) or probenecid (200 mg kg^–1; A) in CD1 mice, and respective areas under the curve (AUCs) of TMAO levels were calculated (B). Values are represented as the mean ± standard error of the mean of 5–6 animals. *Significantly different from the control group (one‐way ANOVA with Dunnett's multiple comparison post‐test, P < 0.05)