Figure 4.

The effects of acute administration of furosemide after concomitant trimethylamine‐N‐oxide (TMAO) administration on the plasma and tissue concentration of TMAO in mice. TMAO concentrations were determined in plasma (A) and in kidney, heart and liver tissues (B) 60 min after TMAO (10 mg kg^–1) administration with furosemide (50 mg kg^–1) in CD1 mice. Values are represented as the mean ± standard error of the mean of 6 animals. *Significantly different from the control group (Unpaired t test, P < 0.05)