Figure 5.

The effects of acute administration of furosemide after concomitant trimethylamine‐N‐oxide (TMAO) administration on the urinary excretion of TMAO in mice. TMAO concentrations were determined in urine (A), and excretion rate of TMAO in urine was calculated (B) at every 30 min interval until 2 h after TMAO (10 mg kg^–1) administration with furosemide (50 mg kg^–1) in CD1 mice. Values are represented as the mean ± standard error of the mean of 3–6 animals. *Significantly different from the control group (unpaired t test, P < 0.05)