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. 2018 Mar 2;33(1):44–58. doi: 10.1007/s12250-018-0011-8

Fig. 1.

Fig. 1

Schematic description of the species Orthohepevirus C genomes and viral proteins. Different reading frames are denoted on the right, ORF1 is considered as frame 1. HEV-C1 is relative to the reference strain R63 (GenBank Accession No. GU345042); HEV-C2 is relative to the reference strain FRHEV4 (GenBank Accession No. JN998606). ORF1 encodes the non-structural polyprotein, and putative domains of RdHEVAc and RdHEVEm including methyltransferase (Met), macro-domain (X), RNA helicase (Hel) and RNA-dependent RNA polymerase (RdRp) are indicated. ORF2 encodes the capsid protein. ORF3 encodes a small multifunctional protein. The function of particular ORF4 is still unknown (adapted from Sridhar et al. 2017).