Table 2.
Genomic features and putative domains of novel rodent orthohepevirus strains
| Novel rodent orthohepeviruses genomic region and putative domains | Start site/end site | Functional description (Cao and Meng 2012; Kamar et al. 2012; van Tong et al. 2016) | |||
|---|---|---|---|---|---|
| RdHEVAc14 | RdHEVAc86 | RdHEVEm40 | RdHEVEm67 | ||
| 5′-UTR | nt 1/18 | nt 1/18 | nt 1/41 | nt 1/41 | |
| ORF1 | nt 19/4935 aa 1/1639 |
nt 19/4935 aa 1/1639 |
nt 42/4907 aa 1/1622 |
nt 42/4907 aa 1/1622 |
Non-structural protein |
| Met | nt 78/1275 aa 26/425 |
nt 78/1275 aa 26/425 |
nt 72/1269 aa 26/423 |
nt 72/1269 aa 26/423 |
Catalyze the capping of viral RNA, guanine-7-methyltransferase and guanyltransferase activities |
| X | nt 2076/2373 aa 692/791 |
nt 2076/2373 aa 692/791 |
nt 2187/2478 aa 729/826 |
nt 2190/2481 aa 730/827 |
ADP-ribose metabolism and post-translational modifications |
| Hel | nt 2763/3405 aa 921/1135 |
nt 2763/3405 aa 921/1135 |
nt 2697/3345 aa 899/1115 |
nt 2697/3345 aa 900/1116 |
NTPase and RNA unwinding activities |
| RdRp | nt 3666/4872 aa 1222/1624 |
nt 3555/4872 aa 1185/1624 |
nt 3465/4821 aa 1155/1607 |
nt 3468/4824 aa 1156/1608 |
Replicate the genomic RNA through an anti-genomic RNA intermediate |
| ORF2 | nt 4962/6902 aa 1/647 |
nt 4962/6902 aa 1/647 | nt 4888/6888 aa 1/667 |
nt 4891/6891 aa 1/667 |
Capsid protein |
| ORF3 | nt 4951/5268 aa 1/106 |
nt 4951/5268 aa 1/106 |
nt 4934/5269 aa 1/112 |
nt 4937/5272 aa 1/112 |
Multifunctional phosphoprotein that can modulate cellular signaling and is related to particle secretion |
| ORF4 | nt 35/553 aa 1/173 |
nt 35/553 aa 1/173 |
NA | NA | Unknown |
| 3′-UTR | nt 6903/6967 | nt 6903/6966 | nt 6889/6961 | nt 6892/6964 | |
Homology to known protein domains were identified using Motif Scan (http://myhits.isb-sib.ch).
Nucleotide for nt; amino acid for aa; and not available for NA. Viral methyltransferase for Met; Marco domain for X; Viral RNA helicase for Hel; and RNA-dependent RNA polymerase for RdRp.