Figure 3.

Conditioning Lesions Activate Intrinsic Neuronal Growth State

(A–C) Seven days after a peripheral conditioning lesion, GAP-43 expression (green) is significantly upregulated in ipsilateral DRGs at C7 (A) compared with contralateral DRGs (B), quantified in (C) (n = 3 replicates). TUJ1 is a mature neuronal marker.

(D–I) Conditioning lesions also upregulate expression of (D–F) pSTAT3 and (G–I) c-Jun in conditioned DRGs (n = 3).

Data are presented as mean ± SEM. ^∗p < 0.05, ^∗∗p < 0.01, Student's t test. Scale bars, 100 μm.