Table 2.
Distribution of Hemolymphoproliferative Neoplasia in Both Decedents and/or Pre-terminally Sacrificed Animals and at Termination
| Group (n = 15) | Animal Number and Sex | ICD or TK (days) | Lymphomas | VCN PB (BM) | VCN Tissue | % CD45.1 /(CD45.1+Cd45.2) in PBa |
|---|---|---|---|---|---|---|
| th3/+ GLOBE LV | 617 F | ICD (154) | lymphoma systemic | 12.92 (16.53) | 8.69 | 67.3 |
| 690 M | ICD (181) | lymphoma systemic | 15.87 (NA) | 7.82 | 80.9 | |
| 627 F | TK | lymphoma systemic | 6.2 (0.14) | NA | 12.8 | |
| 605 M | TK | histiocytic sarcoma systemic | 7.44 (10.87) | NA | 88.1 | |
| th3/+ MOCK | 654 F | ICD (260) | lymphoma systemic | – | – | 62.2 |
| 647 F | TK | lymphoma lung | – | – | 0.2 | |
| th3/+ | 661 M | TK | lymphoma mesenteric lymph node | – | – | – |
| 664 M | TK | lymphoma Peyer’s patch jejunum | – | – | – | |
| 665 M | TK | lymphoma mesenteric lymph node | – | – | – | |
| 677 F | TK | lymphoma Peyer’s patch ileum | – | – | – | |
| 689 F | TK | lymphoma liver | – | – | – |
ICD, intercurrent death (days after transplantation); TK, terminal kill sacrificed at 50 ± 1 week; NA, not available; F, female; M, male; –, not applicable.
a
Percent chimerism in PB at the latest time point.