Table 5.
Univariate and multivariate regression analysis for predictors of AKI occurrence in our CRS and HIPEC population.
| Univariate Analysis |
Multivariate Analysis |
|||
|---|---|---|---|---|
| Hazard Ratio [CI] | P | Hazard Ratio [CI] | P | |
| Age | 0.983 [0.903–1.070] | 0.698 | NS | NS |
| Sex | 1.069 [0.111–9.318] | 0.954 | NS | NS |
| Charlson score ≥1 | 2.402 [1.850–5.812] | 0.031 | 1.713 [0.921–4.965] | 0.062 |
| Baseline creatinine | 1.661 [0.020–8.862] | 0.450 | NS | NS |
| PCI | 1.216 [1.088–1.497] | 0.045 | 1.104 [0.908–1.410] | 0.140 |
| CC-0/1 | 1.131 [0.885–1.671] | 0.492 | NS | NS |
| Operative time | 1.004 [0.985–1.022] | 0.696 | NS | NS |
| EBL | 2.401 [2.109–2.817] | 0.001 | 1.517 [1.462–1.808] | 0.007 |
| Intraoperative fluids | 1.398 [1.091–1.864] | 0.036 | 0.920 [0.466–2.185] | 0.187 |
| Postoperative fluids | 0.910 [0.762–1.824] | 0.152 | NS | NS |
| HIPEC agent | ||||
| Cisplatin | 3.644 [2.115–6.753] | 0.012 | 3.017 [0.919–6.741] | 0.058 |
| Mitomycin C | 1.823 [0.112–3.629] | 0.685 | NS | NS |
Numbers in bold: statistically significant.
AKI = Acute Kidney Injury, CC = Completeness of Cytoreduction, CI = 95% Confidence Interval, CRS = Cytoreductive Surgery, EBL = Estimated Blood Loss, HIPEC = Hyperthermic Intraperitoneal Chemotherapy, PCI = Peritoneal Carcinomatosis Index.