TABLE 1.
Characteristics of the Study Population, OMAR Retention, and Hemodynamic Parameters During Positron Emission Tomography/Computed Tomography
| CON | AOB | p Value | |
|---|---|---|---|
| Age, yrs | 50 (47–65) | 47 (24–55) | 0.101 |
| Female/male | 2/3 | 3/4 | − |
| BMI, kg/m2 | 25 (23–25) | 39 (38–56) | 0.0001 |
| Waist, cm | 80 (79–84) | 134 (127–151) | 0.0001 |
| Waist/hip ratio | 0.83 (0.81–0.83) | 1.05 (0.96–1.09) | 0.0001 |
| Cholesterol, mg/dl | 180 (170–211) | 168 (155–183) | 0.087 |
| LDL, mg/dl | 115 (110–144) | 97 (88–123) | 0.048 |
| HDL, mg/dl | 43 (41–47) | 39 (37–44) | 0.032 |
| Triglyceride, mg/dl | 77 (56–109) | 93 (77–116) | 0.254 |
| Glucose, mg/dl | 93 (80–102) | 109 (82–114) | 0.119 |
| C-reactive protein, mg/dl | 1.6 (0.9–2.1) | 6.5 (3.1–12.1) | 0.004 |
| Hemodynamic parameters before [11C]-OMAR injection | |||
| HR, beats/min | 67 (55–84) | 72 (55–90) | 0.511 |
| SBP, mm Hg | 125 (116–133) | 133 (110–137) | 0.520 |
| DBP, mm Hg | 61 (55–72) | 71 (52–90) | 0.259 |
| RPP, mm Hg/min | 8,710 (6,490–11,172) | 9,520 (7,315–10,720) | 0.486 |
| MAP, mm Hg | 82 (75–92) | 92 (71–106) | 0.318 |
| Hemodynamic parameters after [11C]-OMAR injection | |||
| HR, beats/min | 70 (61–77) | 72 (65–84) | 0.763 |
| SBP, mm Hg | 120 (118–124) | 133 (116–140) | 0.226 |
| DBP, mm Hg | 62 (60–68) | 71 (56–78) | 0.353 |
| RPP, mm Hg/min | 8,260 (7,15–11,730) | 9,588 (7,325–10,960) | 0.538 |
| MAP, mm Hg | 81 (75–97) | 93 (76–96) | 0.286 |
| OMAR retention, %/min | 0.47 (0.13–1.31) | 5.68 (1.88–6.89) | 0.006 |
| MBF, ml/g/min | 0.67 (0.60–0.88) | 0.74 (0.60–0.95) | 0.396 |
| NMBF, ml/g/min | 0.73 (0.63–1.57) | 0.92 (0.60–1.13) | 0.913 |
| CVR, mm Hg/ml/min | 117 (86–149) | 120 (81–142) | 0.766 |
| LVEF, % | 62 (50–63) | 52 (51–61) | 0.092 |
| EDV, ml | 128 (72–135) | 116 (84–146) | 0.502 |
| ESV, ml | 50 (25–66) | 57 (32–71) | 0.249 |
| SV, ml | 62 (48–83) | 60 (52–78) | 0.992 |
| PFR, s | 1.87 (1.76–2.22) | 1.78 (1.44–2.58) | 0.796 |
| TPFR, s | 137 (133–169) | 155 (135–181) | 0.317 |
| 1/3 MFR, s | 1.29 (1.12–1.44) | 1.14 (1.11–1.42) | 0.184 |
Values are median (range) or n.
AOB = advanced obesity; BMI = body mass index; CON = control; CVR = coronary vascular resistance; DBP = diastolic blood pressure; EDV = end-diastolic volume; ESV = end-systolic volume; HDL = high-density lipoprotein; HR = heart rate; LDL = low-density lipoprotein; LVEF = left ventricular ejection fraction; MAP = mean arterial pressure; MBF = myocardial blood flow; MFR = mean filling rate; NMBF = normalized myocardial blood flow; PFR = peak filling rate; RPP = rate-pressure product; SBP = systolic blood pressure; SV = stroke volume;TPFR = time to peak filling rate.