TABLE 3.
[11C]-0MAR (%ID/g Tissue) | |||
---|---|---|---|
Vehicle | Rimonabant 1 mg | Rimonabant 5 mg | |
Heart | 4.63 (4.00–5.23) | 5.11 (3.68–6.99) | 1.94 (1.91–2.15) |
Blood | 1.19 (1.10–1.33) | 1.99 (1.08–2.16) | 0.54 (0.38–0.72) |
Cerebellum | 2.43 (1.72–2.74) | 1.50 (1.43–1.78) | 0.79 (0.78–0.80) |
Thalamus | 1.78 (1.25–2.07) | 1.33 (1.24–1.49) | 0.57 (0.22–0.63) |
Values are median (range).
%ID = percentage of injected dose per gram of tissue;
vehicle = mouse without rimonabant application.