Figure 1.

Plasma folate (ng/mL) of participants in the treatment group at 3 months (ordinate) compared to capsule counts in bottles returned at the 3-month visit and to questionnaire responses at the 3-month visit. The results are divided into ‘under-adherent’ (<85.7% of doses taken), and ‘adherent’ (≥85.7% of doses taken) by the stringent definition. The median folate value for the under-adherent (n = 64) and adherent (n = 192) groups according to capsule count were 1888 and 2452, respectively (p = 0.005). The median folate value for the under-adherent (n = 27) and adherent (n = 397) groups according to questionnaires were 1255 and 2424, respectively (p = 0.002).

Notes: The central line in the box indicates the 50th percentile (median) value; the + indicates the mean; the box represents the interquartile range (IQR) (25th and 75th percentiles), the ends of the whiskers represent the maximum value within 1.5 times the IQR, and the small boxes represent outlier values greater than 1.5 times the IQR.