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. 2018 Oct 10;16:179. doi: 10.1186/s12916-018-1163-y

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Volcano plot of 45 exosomal miRNAs. Volcano plots of p values vs fold changes compare the expression of exosomal miRNAs in 435 BC (a), 211 HER2-positive (b), and 224 TNBC patients (c) with that of 20 healthy women, as well as between HER2-positive and TNBC patients (d). The grey dashed line refers to the threshold value corresponding to a corrected p value of p = 0.05. Significantly downregulated exosomal miRNAs are shown as green dots, significantly upregulated exosomal miRNAs as red dots. Grey dots represent non-significant changes. p values are calculated by the Student t test and corrected according to the Benjamini and Hochberg method