Table 2.
The Significantly different metabolites in heart of mice
| Class | Metabolites | FC(Diabetic/Control) | log2(FC) | Vip Value | p Value |
|---|---|---|---|---|---|
| Hydroxyl-fatty-acyl-carnitine | 2-Hydroxymyristoylcarnitine(18:0) | 3.182 | 1.66993 | 1.133 | 0.0472 |
| 3-Hydroxy-cis-tetradecenoylcarnitine(14:1) | 10.212 | 3.35219 | 1.174 | 0.0308 | |
| 3-Hydroxy-tetradecadiencarnitine(14:2) | 2.552 | 1.35163 | 1.230 | 0.0163 | |
| 3-Hydroxyhexadecanoylcarnitine(16:0) | 11.681 | 3.54609 | 1.230 | 0.0323 | |
| 3-Hydroxy-hexadecenoylcarnitine(16:1) | 2.500 | 1.32193 | 1.188 | 0.0433 | |
| 3-Hydroxyhexadecadienoylcarnitine(16:2) | 2.721 | 1.44414 | 1.146 | 0.0450 | |
| 3-Hydroxy-octadecenoylcarnitine(18:1) | 3.077 | 1.62152 | 1.139 | 0.0465 | |
| 12-Hydroxy-octadecanoylcarnitine(18:0) | 3.293 | 1.71940 | 1.061 | 0.0467 | |
| Fatty-acyl-carnitine | Decenoylcarnitine(10:1) | 0.033 | −4.93669 | 1.324 | < 0.0001 |
| Dodecanoylcarnitine(12:0) | 0.202 | −2.30685 | 1.335 | < 0.0001 | |
| Tetradecanoylcarnitine(14:0) | 0.481 | −1.05589 | 1.076 | < 0.0001 | |
| Docosa-pentaenoyl carnitine(22:5) | 0.455 | − 1.13488 | 1.247 | 0.0079 | |
| L-Palmitoylcarnitine(16:0) | 2.421 | 1.27560 | 1.062 | 0.0107 | |
| trans-Hexadec-enoyl carnitine(16:1) | 2.132 | 1.09221 | 1.112 | 0.0224 | |
| Hexadecadienoylcarnitine(16:2) | 2.594 | 1.37518 | 1.349 | 0.0630 | |
| Stearoylcarnitine(18:0) | 2.404 | 1.26544 | 1.050 | 0.0130 | |
| Linoelaidyl carnitine(18:2) | 2.053 | 1.03773 | 1.016 | 0.0182 | |
| Gamma-linolenyl carnitine(18:3) | 2.202 | 1.13881 | 1.123 | 0.0189 | |
| Arachidyl carnitine(20:0) | 0.429 | −1.22219 | 1.095 | 0.0200 | |
| Fatty acid | Eicosenoic acid(20:1) | 0.459 | −1.12499 | 1.347 | < 0.0001 |
| Eicosapentaenoic acid(20:5) | 0.479 | −1.06212 | 1.143 | < 0.0001 | |
| Docosadienoate(22:2) | 0.089 | −3.48877 | 1.343 | < 0.0001 | |
| Docosahexaenoate(22:6) | 0.067 | −3.90785 | 1.322 | < 0.0001 | |
| Tetracosahexaenoic acid(24:6) | 0.215 | −2.21475 | 1.384 | < 0.0001 | |
| Docosapentaenoic acid(22:5) | 2.084 | 1.05936 | 1.275 | 0.0079 | |
| Triglyceride (TG) | TG 14:1/18:4/14:1 | 0.365 | −1.45418 | 1.152 | 0.0284 |
| TG 18:3/18:4/18:3 | 0.263 | −1.92638 | 1.189 | 0.0024 | |
| TG 20:4/24:1/20:4 | 0.350 | −1.51450 | 1.046 | 0.0033 | |
| TG 14:1/20:5/14:1 | 6.763 | 2.75766 | 1.295 | < 0.0001 | |
| TG 16:1/18:0/16:1 | 3.448 | 1.78576 | 1.065 | 0.0268 | |
| Diacylglycerol (DG) | DG 20:0/24:1/0:0 | 0.411 | −1.28451 | 1.335 | < 0.0001 |
| DG 22:0/0:0/22:6 | 0.109 | −3.20398 | 1.089 | 0.0078 | |
| DG 24:1/22:0/0:0 | 0.454 | −1.13881 | 1.049 | 0.0006 | |
| DG 24:1/24:0/0:0 | 0.354 | −1.49621 | 1.206 | 0.0005 | |
| DG 14:0/20:5/0:0 | 2.538 | 1.34369 | 1.372 | < 0.0001 | |
| DG 14:1/22:6/0:0 | 4.715 | 2.23726 | 1.393 | < 0.0001 | |
| DG 18:4/18:4/0:0 | 4.079 | 2.02822 | 1.395 | < 0.0001 | |
| phospholipid | |||||
| Phosphatidylcholine (PC) | PC 14:0/16:1 | 0.135 | −2.89414 | 1.026 | 0.0150 |
| PC 14:0/18:2 | 0.228 | −2.13027 | 1.030 | 0.0094 | |
| PC 14:0/22:5 | 0.409 | −1.28924 | 1.091 | 0.0340 | |
| PC 14:1/22:6 | 0.103 | −3.27769 | 1.192 | 0.0014 | |
| PC P-16:0/18:3 | 0.305 | −1.71326 | 1.050 | 0.0121 | |
| PC P-16:0/20:3 | 0.392 | −1.35276 | 1.333 | 0.0003 | |
| PC P-18:1/18:3 | 0.353 | −1.50131 | 1.075 | 0.0236 | |
| PC 18:3/P-16:0 | 0.411 | −1.28155 | 1.043 | 0.0199 | |
| PC 20:5/P-18:1 | 0.410 | −1.28570 | 1.056 | 0.0258 | |
| PC 20:5/18:3 | 0.110 | −3.18412 | 1.712 | 0.0240 | |
| PC 20:5/14:0 | 0.428 | −1.22342 | 1.243 | 0.0147 | |
| PC 14:1/20:5 | 2.075 | 1.05311 | 1.303 | < 0.0001 | |
| PC 16:0/22:5 | 2.316 | 1.21164 | 1.163 | 0.0023 | |
| PC 18:2/22:6 | 6.391 | 2.67604 | 1.086 | 0.0056 | |
| PC 22:4/16:0 | 2.178 | 1.12300 | 1.301 | < 0.0001 | |
| PC 22:4/24:1 | 2.018 | 1.01293 | 1.288 | < 0.0001 | |
| PC 22:5/16:0 | 2.358 | 1.23756 | 1.207 | 0.0011 | |
| PC 22:6/18:1 | 2.065 | 1.04614 | 1.211 | 0.0012 | |
| PC 22:6/18:2 | 5.212 | 2.38184 | 1.161 | 0.0019 | |
| Lysophosphatidylcholine (LysoPC) | LysoPC 16:1 | 0.203 | −2.30217 | 1.254 | < 0.0001 |
| LysoPC 20:2 | 0.072 | −3.79286 | 1.282 | < 0.0001 | |
| LysoPC 22:1 | 0.130 | −2.94823 | 1.201 | 0.0012 | |
| LysoPC 22:2 | 0.122 | −3.04002 | 1.213 | 0.0010 | |
| LysoPC 22:6 | 0.128 | −2.96532 | 1.208 | 0.0011 | |
| LysoPC 14:1 | 2.016 | 1.01150 | 1.005 | 0.0243 | |
| LysoPC 18:0 | 2.145 | 1.10098 | 1.023 | 0.0108 | |
| LysoPC P-18:1 | 2.111 | 1.07793 | 1.030 | 0.0101 | |
| LysoPC 20:3 | 2.254 | 1.17249 | 1.092 | 0.0055 | |
| Phosphoethanolamine (PE) | PE 14:0/14:0 | 0.028 | −5.16792 | 1.276 | < 0.0001 |
| PE P-16:0e/0:0 | 0.167 | −2.58448 | 1.184 | 0.0016 | |
| PE O-16:0/18:1 | 0.091 | −3.46205 | 1.114 | 0.0091 | |
| PE P-18:0/18:3 | 0.338 | −1.56365 | 1.171 | 0.0232 | |
| PE 18:4/18:4 | 0.122 | −3.02998 | 1.213 | 0.0010 | |
| PE 22:0/14:0 | 0.259 | −1.94935 | 1.440 | < 0.0001 | |
| PE 22:6/18:0 | 0.303 | −1.72072 | 1.312 | < 0.0001 | |
| PE 14:0/18:3 | 8.300 | 3.05311 | 1.423 | < 0.0001 | |
| PE 16:1/20:1 | 5.469 | 2.45128 | 1.352 | < 0.0001 | |
| PE P-18:1/20:4 | 3.854 | 1.94636 | 1.287 | < 0.0001 | |
| PE 22:6/20:0 | 2.035 | 1.02503 | 1.282 | < 0.0001 | |
| Lysophosphatidylethanolamine (LysoPE) | LysoPE 14:0 | 0.465 | −1.10434 | 1.158 | 0.0022 |
| LysoPE 18:1 | 0.315 | −1.66585 | 1.268 | < 0.0001 | |
| LysoPE 20:1 | 0.150 | −2.73314 | 1.232 | 0.0007 | |
| LysoPE 22:1 | 0.209 | −2.26093 | 1.258 | < 0.0001 | |
| LysoPE 22:2 | 0.190 | −2.39890 | 1.237 | 0.0006 | |
| LysoPE 22:6 | 0.122 | −3.03386 | 1.213 | 0.0010 | |
| LysoPE 24:6 | 0.116 | −3.11103 | 1.248 | 0.0005 | |
| LysoPE 22:0 | 2.026 | 1.01863 | 1.021 | 0.0326 | |
| LysoPE 22:4 | 2.339 | 1.22589 | 1.214 | 0.0008 | |
| LysoPE 24:1 | 3.518 | 1.81476 | 1.180 | 0.0048 | |
| phosphatidic acid (PA) | PA 20:4e/2:0 | 0.127 | −2.97911 | 1.175 | 0.0019 |
| Lysophosphatidic acid (LysoPA) | LysoPA 18:1 | 0.202 | −2.30918 | 1.203 | 0.0011 |
| Phosphatidylglycerol (PG) | PG 12:0/18:4 | 0.165 | −2.59837 | 1.235 | 0.0006 |
| PGP 16:0/16:0 | 0.109 | −3.19141 | 1.185 | 0.0210 | |
| PG 18:1/16:1 | 0.168 | −2.57628 | 1.297 | < 0.0001 | |
| PG 18:1/18:1 | 0.109 | −3.20383 | 1.211 | 0.0010 | |
| PG 18:1/20:4 | 0.110 | −3.18713 | 1.207 | 0.0011 | |
| PG 18:3/22:5 | 0.106 | −3.24031 | 1.289 | < 0.0001 | |
| PG 16:0/18:3 | 6.018 | 2.58928 | 1.353 | < 0.0001 | |
| PG 18:1/18:3 | 2.525 | 1.33628 | 1.078 | 0.0058 | |
| Phosphatidylserine (PS) | PS 12:0/18:2 | 0.163 | −2.61965 | 1.260 | < 0.0001 |
| PS 14:1/20:4 | 0.117 | −3.09238 | 1.189 | 0.0014 | |
| PS 18:0/18:1 | 0.478 | −1.06626 | 1.334 | < 0.0001 | |
| PS 18:0/22:5 | 0.394 | −1.34426 | 1.137 | 0.0055 | |
| PS 18:1/18:1 | 0.412 | −1.27977 | 1.611 | 0.0279 | |
| PS 20:4/16:1 | 0.274 | −1.86632 | 1.293 | < 0.0001 | |
| PS 18:0/18:0 | 5.065 | 2.34056 | 1.257 | < 0.0001 | |
| PS 20:3/18:0 | 5.523 | 2.46545 | 1.230 | 0.0007 | |
| Phosphatidylinositol (PI) | PI 18:0/16:0 | 0.457 | −1.12829 | 1.064 | 0.0211 |
| PI 22:0/0:0 | 0.130 | −2.94505 | 1.203 | 0.0012 | |
| PI 16:0/16:0 | 2.180 | 1.12433 | 1.211 | 0.0010 | |
| PI 16:0/16:1 | 2.423 | 1.27679 | 1.176 | 0.0020 | |
| Sphingomyelin (SM) | SM d18:0/16:0 | 0.100 | −3.32034 | 1.121 | 0.0127 |
| SM d18:0/16:1 | 0.303 | −1.72072 | 1.058 | 0.0358 | |
| SM d18:0/18:1 | 0.126 | −2.98841 | 1.208 | 0.0010 | |
| SM d18:0/22:0 | 0.329 | −1.60549 | 1.055 | 0.0236 | |
| SM d18:0/22:3 | 0.227 | −2.14176 | 1.342 | < 0.0001 | |
| SM d18:0/26:1 | 0.099 | −3.33914 | 1.202 | 0.0012 | |
FC fold change, VIP value variable importance in the projection; p Value, from Student t test and vs. diabetic group; Metabolites, lipids displaying significant changes between control and diabetic heart (P < 0.05 and VIP > 1)