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. 2018 Oct 9;24:647–666.

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Copyright © 2018 Molecular Vision.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited, used for non-commercial purposes, and is not altered or transformed.

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Inhibition of AP-1 activity alters NaCl-induced expression of various genes in RPE cells. The mRNA levels were determined with real-time reverse transcription (RT)–PCR analysis after stimulation of the cells for 6 h with high (+ 100 mM) NaCl, and are expressed as folds of the unstimulated control. AP-1 activity was inhibited with SR11302 (SR; 5 µM). The expression levels of the following genes were determined: HIF-1α, NFAT5, VEGF-A, bFGF, HB-EGF, PlGF, TGF-β2, NLRP3, COX-2, aquaporins 5 (AQP5) and 8 (AQP8), pro-IL-1β, and aldose reductase (AR). Each bar represents data obtained in five to eight independent experiments using cell lines from different donors. Significant difference versus unstimulated control: *p<0.05. ●p<0.05. n.s., not significant.