Table 2.
Dopamine replacement therapy and comorbidity of study patients expressed by drug profiles
| Diagnosis/age | Female/male (n) | Levodopa (n) (mg)a | Dopamine agonists (n) | NMDA inhibitor (n) | Advanced therapyb (n) | Neuroleptics (n) | Anxiolytics (n) | Antidepressants (n) |
|---|---|---|---|---|---|---|---|---|
| IPD >75 years | 15/11 | 14/11 725/450 |
4/4 | 3/6 | 1/1 | 2/1 | 3/6 | 7/1 |
| SP >75 years | 12/13 | 8/7 150/275 |
2/5 | 1/0 | 0/0 | 3/5 | 4/6 | 6/3 |
| IPD ≤75 years | 12/18 | 12/18 525/550 |
8/7 | 3/7 | 1/3 | 0/0 | 2/1 | 2/2 |
| SP ≤75 years | 10/11 | 8/8 300/450 |
2/4 | 0/1 | 0/0 | 1/2 | 5/1 | 4/1 |
|
| ||||||||
| Antidiabetics (n) | Antihypertensive drugs (n) | Antiorthostaic drugs (n) | Laxatives (n) | Vitamin B12/folic acid (n) | Analgesics (n) | Drugs for insomnia | ||
|
| ||||||||
| IPD >75 years | 15/11 | 1/0 | 2/4 | 2/2 | 9/8 | 8/4 | 11/2 | 3/2 |
| SP >75 years | 12/13 | 3/3 | 8/3 | 0/1 | 5/6 | 4/4 | 10/6 | 5/0 |
| IPD ≤75 years | 12/18 | 0/1 | 4/4 | 0/1 | 5/11 | 1/6 | 8/4 | 2/3 |
| SP ≤75 years | 10/11 | 1/1 | 5/3 | 0/0 | 6/4 | 4/3 | 1/5 | 3/2 |
Notes:
a
Equipotent doses following reference.26
b
Duodopa infusion therapy, apomorphine infusion therapy, or Deep Brain Stimulation.
Abbreviations: IPD, idiopathic Parkinson’s disease; SP, secondary Parkinsonism; NMDA, N-metyl-D-aspartat.