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. 2018 Oct 4;13:5971–5990. doi: 10.2147/IJN.S171224

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© 2018 Pang et al. This work is published and licensed by Dove Medical Press Limited

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4T1/3T3 mixed tumor spheres construction and combination therapy effects on mixed tumor spheres.

Notes: (A) CLSM section images from top to bottom of spheres. Green fluorescence (DiO) indicated 3T3. Red was pseudo-fluorescence indicating all cells. (B) Tumor spheres volume changed after treatments with PBS, tranilast, DTX-Ms, CC therapy, TC therapy (TI =24 hours). The concentrations of DTX-Ms and tranilast were 100 and 2,000 µM, respectively. n=4 or 5. *P<0.05, **P<0.01.

Abbreviations: CLSM, confocal laser scanning microscope; DiO, 3,3′-dioctadecyloxacarbocyanine perchlorate; DTX-Ms, docetaxel micelles; TC therapy, two-stage combination therapy; CC therapy, co-dose combination therapy.