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Illustration of the two-stage therapy.
Notes: Tranilast was pre-dosed to break down the CAFs barrier. Along with active CAFs weakening, IFP was reduced and microvessels were normalized. The following DTX micelles penetration and retention were improved after tumor microenvironment restoration.
Abbreviations: CAF, cancer-associated fibroblast; IFP, interstitial fluid pressure; DTX, docetaxel.
